Pregnancy Home > Clomid and Twins

Clomid® (clomiphene citrate) is a prescription medication used to treat infertility in women. Due to the way it works, this drug increases the chances of multiple births, including twins, triplets, or more.
In clinical studies, about 30 percent of women taking Clomid became pregnant. Of these pregnancies, 7.98 percent were multiple births, including:
  • Twins -- 6.9 percent
  • Triplets -- 0.5 percent
  • Quadruplets -- 0.3 percent
  • Quintuplets -- 0.1 percent.
Of the twins, there were five times as many fraternal twins as identical twins.
The increased chance of having multiple births with Clomid is due to the ovary-stimulating effects from the medication. It is important to remember that pregnancies with multiple births are more dangerous than single pregnancies. For this reason, it is generally not recommended to take Clomid for the purpose of having twins.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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