Pitocin Drug Interactions

Dinoprostone and misoprostol may cause problems when used in combination with Pitocin. These drug interactions may cause abnormally strong or frequent contractions. To help reduce the risk for these complications, you may not receive a dose of Pitocin for several hours after using dinoprostone or misoprostol. In some cases, certain dinoprostone products should not be used at all with Pitocin.

An Overview of Interactions With Pitocin

Pitocin® (oxytocin) can potentially react with a couple of other medications. Some of the products that may lead to drug interactions with Pitocin include:
 
 

Pitocin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Pitocin is combined with any of the drugs listed above.
 
Dinoprostone
Dinoprostone may increase the effects of Pitocin, potentially causing abnormally strong or frequent contractions. To minimize the risk for this interaction, Pitocin should be given at least 30 minutes after dinoprostone vaginal insert is removed and at least 6 to 12 hours after dinoprostone vaginal gel is given. It is generally recommended that dinoprostone vaginal suppository not be used in combination with Pitocin.
 
Misoprostol
Misoprostol may increase the effects of Pitocin, potentially causing abnormally strong or frequent contractions. Giving Pitocin 6 to 12 hours after misoprostol may help reduce the risk for this interaction.
 
Pregnancy and Pain

Pitocin Drug Information

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