Makena Warnings and Precautions

Before starting Makena, talk to your healthcare provider if you have high blood pressure, depression, diabetes, or any other medical conditions, including allergies. Other warnings with Makena include precautions about avoiding this drug if you have ever had a blood clot, breast cancer, or cholestatic jaundice of pregnancy. You will likely require extra monitoring if you develop high blood pressure or jaundice during treatment.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to receiving Makena™ (hydroxyprogesterone caproate) if you have:
Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Makena

Some warnings and precautions to be aware of prior to using Makena include the following:
  • Makena can cause fluid retention (water weight gain), which can cause problems for women with seizures, epilepsy, migraines, heart problems, or kidney disease.
  • Let your healthcare provider know if you have depression or a history of depression, as Makena could make this condition worse.
  • Let your healthcare provider know right away if you have any vision changes or have a migraine for the first time while using Makena.
  • If you have diabetes, your healthcare provider may recommend that you monitor your blood sugar more closely when starting or stopping Makena in case you experience any changes in your blood sugar.
  • If you develop a blood clot during treatment, your healthcare provider will probably recommend that you stop using the drug.
  • If you develop yellow skin (jaundice) or high blood pressure while using Makena, your healthcare provider will monitor you closely in order to determine if you should keep using it.
  • Makena can react with a few different medications (see Makena Drug Interactions for more information).
  • Although Makena is intended for use during pregnancy, it is classified as a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown. It was given this rating mostly because the safety of the drug during the first trimester is unclear at this point(see Makena and Pregnancy).
  • The hormones in Makena pass through breast milk. Therefore, if you are still breastfeeding, discuss this with your healthcare provider prior to using the drug (see Makena and Breastfeeding).
Pregnancy and Pain

Makena Drug Information

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