Makena

How Does Makena Work?

Makena is a synthetic (manufactured), long-acting version of progesterone, a hormone that is very important to maintaining a pregnancy. It is not yet known for certain exactly how the drug works to prevent preterm labor.
 

Clinical Effects

In studies, Makena was shown to reduce the risk of preterm birth in women with a history of this condition. Specifically, 37.1 percent of women receiving Makena injections delivered before 37 weeks, compared to 54.9 percent of women receiving placebo injections, which are injections that contained no active ingredients.
 

When and How to Use Makena

Some general considerations to keep in mind when receiving Makena include the following:
 
  • This medication comes as an injection. It is injected by a healthcare provider once a week (once every seven days). It is started sometime between 16 and 21 weeks of pregnancy and continued until 37 weeks of pregnancy.
     
  • The injections are given in the upper-outer area of the buttocks, near the hip.
     
  • For Makena to work properly, it must be given as prescribed.
     

Dosing Information

There is only one standard dosage for this medication, regardless of your age and weight. As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
 
(Click Makena Dosage for more information.)
 
Pregnancy and Pain

Makena Drug Information

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