Pregnancy Home > Prepidil Side Effects

Prepidil can cause reactions in a pregnant woman and her unborn baby. Some of the most common side effects include fetal distress, abnormal uterine contractions, and vomiting. In many cases, reactions to this drug tend to be minor and treated easily. However, make sure you let your healthcare provider know right away if you develop serious problems, such as severe uterine pain or persistent vomiting.

An Introduction to Prepidil Side Effects

Just like any medicine, Prepidil® (dinoprostone vaginal gel) can cause side effects. However, not everyone who receives the drug will have problems. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Prepidil. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Prepidil

Prepidil has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of women given the drug were documented and compared to those that occurred in a similar group of women given a placebo (a vaginal gel that did not contain any active ingredients) or no treatment.
 
In these studies, the most common Prepidil side effects included:
 
  • Fetal distress (an abnormal fetal heart rate) -- in up to 17 percent of women
  • Abnormal uterine contractions -- up to 6.6 percent
  • Any stomach or intestinal side effect (such as vomiting or diarrhea) -- up to 5.7 percent
  • A variable fetal heart rate -- up to 4.3 percent
  • Low fetal heart rate -- up to 4.1 percent
  • Back pain -- up to 3.1 percent
  • Warm feeling in the vagina -- up to 1.5 percent
  • Fever -- up to 1.4 percent.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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