Prepidil (dinoprostone vaginal gel) is approved only for use in pregnant women at the time of delivery. Therefore, it is unlikely that a woman who is breastfeeding would receive Prepidil. When used as recommended, this drug is unlikely to affect breast milk production in the days after childbirth. However, if you plan to breastfeed and have concerns about receiving this drug, talk to your healthcare provider.
Can Breastfeeding Women Receive Prepidil?
At this time, it is not known if Prepidil® (dinoprostone vaginal gel) passes through breast milk in humans. Because the medication is approved only for use in pregnant women who are at or near delivery, it is unlikely to be used while a woman is nursing. If you are breastfeeding or plan to start, talk with your healthcare provider before using Prepidil.
More Information on Prepidil and Breastfeeding
Prepidil has not been studied in breastfeeding women or animals. Therefore, it is unknown whether the medication passes through breast milk, or if it would harm a nursing child.
Prepidil is a hormone-type substance known as a prostaglandin. Prostaglandins are naturally found in breast milk in small amounts, and are thought to help protect the infant's gastrointestinal tract.
When given by mouth, dinoprostone (the active ingredient in Prepidil) can suppress lactation in the first few days after birth. By one month after birth, the drug no longer affects breast milk production. However, Prepidil comes in the form of a gel that is administered intravaginally prior to labor and delivery. When used as recommended, the medication would be unlikely to influence milk production in the days after childbirth.
Talking With Your Healthcare Provider
You should discuss breastfeeding and Prepidil use with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Prepidil [package insert]. New York, NY: Pharmacia and Upjohn Company;2010 February.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed January 23, 2012.
Dinoprostone. Drug Facts and Comparisons. Drug Facts and Comparisons 4.0 [online]. 2012. Available from Wolters Kluwer Health, Inc. Accessed January 25, 2012.
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