Pregnancy Home > Precautions and Warnings With Clomiphene

To help ensure a safe treatment process and to minimize risks, there are numerous precautions and warnings with clomiphene that you should be aware of prior to starting the fertility drug. Clomiphene may potentially cause ovarian hyperstimulation syndrome, vision changes, or multiple births (twins, triplets, or more). The medication is not suitable for everyone; you should not take clomiphene if you have liver disease, uncontrolled thyroid or adrenal problems, abnormal vaginal bleeding, or ovarian cysts.

Clomiphene: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking clomiphene citrate (Clomid®) if you have:
  • Thyroid or adrenal problems
  • A brain tumor
  • Ovarian cysts
  • Polycystic ovarian syndrome (PCOS)
  • Fibroids
  • Depression
  • Liver disease, including liver failure or cirrhosis
  • Abnormal menstrual bleeding (abnormal periods)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or may be pregnant
  • Are breastfeeding.
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Clomiphene Precautions and Warnings

Some warnings and precautions to be aware of with this medication include:
  • Clomiphene is considered a pregnancy Category X medicine. This means that it is likely to cause harm to an unborn baby. Do not use clomiphene if you are or might be pregnant (see Clomid and Pregnancy for more information).
  • It is not known if clomiphene is passed through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this.
  • Clomiphene can cause vision changes, including blurred vision or seeing spots. Be aware that these visions changes could affect your ability to drive or operate heavy machinery.
  • Ovarian hyperstimulation syndrome (OHSS) can occur with clomiphene. OHSS is characterized by enlarged ovaries and can be extremely dangerous. In severe cases, the ovaries could rupture. Symptoms of OHSS include abdominal (or stomach) pain or enlargement, upset stomach (nausea), vomiting, diarrhea, and weight gain. If you have these symptoms, contact your healthcare provider right away.
  • Taking clomiphene increases your chance of multiple pregnancies, including twins, triplets, or more (see Clomid and Twins).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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