Does Folic Acid Work?

Does Folic Acid Work for Methotrexate Toxicity?
Methotrexate is a prescription medication used to treat certain cancers, rheumatoid arthritis, and psoriasis. It works for cancer by interfering with the ability of cells to use folic acid properly, interfering with the cell's ability to grow and divide. Ideally, only cancer cells will be affected, but in reality, healthy cells are also harmed.
Sometimes leucovorin (a specific form of folic acid) is used to "rescue" healthy cells when too much toxicity occurs due to methotrexate. There is some concern that using folic acid may interfere with the anti-cancer effects of methotrexate. Do not take folic acid with methotrexate unless your healthcare provider specifically recommends that you do so. This is probably not a problem if you take methotrexate for uses other than cancer treatment.

Final Thoughts on Folic Acid Effectiveness

Folic acid is effective for several uses, but more research is needed before it can be recommended for some of the more controversial uses (such as for heart disease). Folic acid is clearly effective for preventing certain birth defects and is one of the most important vitamins for pregnant women. Before you use folic acid (especially high doses of folic acid) for uses other than general supplementation, it is a good idea to check with your healthcare provider first.
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Folic Acid Supplements

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