Clomid and Migraines

Clinical studies revealed several side effects of Clomid, and migraines appear to be possible. However, these studies did not reveal how many women not taking the drug experienced migraines, nor did they discriminate between migraines and other types of headaches. If you are taking Clomid and migraines occur, your healthcare provider can recommend treatment options based on your symptoms and their frequency.

 

Does Clomid Cause Migraines?

Several side effects are possible with Clomid® (clomiphene citrate), and migraines may be one of them. This data comes from clinical trials in which the drug was studied extensively and side effects were documented.
 

Clomid and Migraines: Understanding Clinical Trials

Before medicines are approved, they must go through several clinical studies, where thousands of people are given a particular medicine and are then compared to a group of people who were not given the medicine.
 In these studies, side effects are always documented. As a result, it is possible to see which side effects occur, how often they appear, and how they compare to the group not taking the medicine. Side effects are then usually separated into those side effects that occur in more than 1 percent of people (common side effects) and those that occur in less than 1 percent of people (rare side effects).
 
Headaches (including migraines) were reported in up to 1.3 percent of women taking Clomid. These studies did not separate migraine headaches from other types of headaches. They also did not report how many women who did not take Clomid had headaches. Therefore, it is difficult to say the effects of Clomid on migraine headaches. It is also difficult to know whether women with a history of migraines are at increased risk for them during Clomid therapy.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;