Cervidil Warnings and Precautions

If your healthcare provider recommends using Cervidil, it is important that you discuss whether you have had vaginal bleeding during your pregnancy, had a previous C-section, or have a history of asthma. Other precautions with Cervidil include warnings of potential complications that may occur, such as a blood clotting disorder, allergic reactions, and other problems.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Cervidil® (dinoprostone vaginal insert) if you have:
  • Had vaginal bleeding during your pregnancy
  • Had a cesarean section (C-section) in the past
  • Had major surgery on your uterus
  • Any disease or condition that affects your uterus
  • Glaucoma
  • A history of asthma, even as a child
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are breastfeeding or taking any other medications, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Cervidil

Some warnings and precautions to be aware of prior to receiving this medication include the following:
  • Cervidil should only be inserted by a trained healthcare provider in a hospital setting.
  • This medication may increase the risk for a blood clotting disorder that can cause serious bleeding after childbirth. Women who are 30 years of age or older, who had complications during pregnancy, or who have been pregnant for longer than 40 weeks may have a higher risk for this problem.
  • Cervidil has been associated with a serious condition known as anaphylactoid syndrome of pregnancy (sometimes called amniotic fluid embolism). This condition occurs when amniotic fluid enters the bloodstream through the placenta and causes an allergic response. Although it is rare, the condition is life-threatening, as it can lead to heart and lung collapse and bleeding.
  • You and your unborn baby will be closely monitored while the vaginal insert is in place. Your healthcare provider will check your cervix, the strength and frequency of your contractions, and how your baby is doing. The vaginal insert will be removed if:
    • Your contractions are unusually strong, long, or frequent
    • Your baby is in distress
    • You are experiencing certain side effects
    • Active labor begins.
  • Your healthcare provider will also remove Cervidil before you have an amniotomy (artificial rupture of the amniotic sac to induce labor).
  • Because some women may have an increased risk for certain problems from Cervidil use, your healthcare provider may choose to monitor you more closely if:
    • Your "water broke" (ruptured membranes)
    • Your baby is not in the normal head-down position
    • You are carrying more than one baby
    • You have a history of unusually strong or frequent uterine contractions
    • You have glaucoma
    • You have a history of childhood asthma.
  • Cervidil is unlikely to react with most other medications. However, it should not be used at the same time as oxytocin (Pitocin®), although these medications can be used one after the other, with a short break in between (see Cervidil Drug Interactions).
  • Cervidil is a pregnancy Category C medication. This means the medicine may not be safe for use during pregnancy (see Cervidil and Pregnancy), although obviously it is intended for use only in pregnant women.
  • It is unknown whether Cervidil passes through breast milk, although it is unlikely to do so. If you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Cervidil and Breastfeeding).
Pregnancy and Pain

Cervidil Drug Information

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